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Classification of Parkinsonism

February 19, 2016 | Tags: Categories for this post are: Parkinson’s Disease

Parkinsonism is classified into four main categories as follows.

A. Primary (idiopathic) Parkinsonism

1. Parkinson’s Disease (sporadic and genetic)

B. Secondary Parkinsonism (Acquired)

1. Drugs Induced: Antipsychotics such as dopamine receptors blocking drugs, antiemetics such as metoclopramide, dopamine depleting drugs like reserpine, tetrabenzine, alpha-methyl-dopa, lithium, flunarizine, cinnarizine.
2. Infectious: Post encephalitic
3. Toxins: MPTP, CO, Mn, Hg, CS2
4. Vascular: multi-infarct state of brain
5. Trauma: Pulgilistic encephalopathy
6. Hemiatrophy hemi parkinsonism
7. Brain tumors in certain locations such as basal ganglia
8. Hydrocephalus
9. Hypoxia
10. Metabolic

C. Atypical Parkinsonism

1.Progressive supranuclear palsy
2. Multiple system atrophy
3. Corticobasal ganglionic degeneration
4. ALS-Parkinsonism-Dementia – complex of Guam

D. Familial Neurodegenerative Disease causing Parkinsonism

1. Huntington’s disease
2. Wilson’s disease
3. Hllervorden-spatz disease
4. Olivopontocerebellar and spinocerebellar degeneration
5. Familial basal ganglia calcification
6. Familial Parkinsonism with peripheral neuropathy
7. Neuroacanthocytosis