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Manganese role in the development of Secondary parkinsonism?

February 11, 2016 | Tags: Categories for this post are: Theories

People who abuse methcathinone—a psychoactive stimulant similar to amphetamines and cocaine—show increased levels of manganese (one of its ingredients) in the blood. When this is accompanied by extra-pyramidal syndrome and varying MRI signals from the basal ganglia, it implicates manganese as a cause of parkinsonism. Others have suggested that a prenatal exposure to dopaminergic neuronal... Read more

What toxins have been linked to secondary parkinsonism?

January 1, 2016 | Tags: > Categories for this post are: Parkinson’s Disease,Theories

Exposure to a number of toxins has been associated with parkinsonism, including: • Mercury- this includes usage in dental amalgams (in the past), in dental fluorescent lamps, preservative thimerosol in vaccines and thermometers. • MPTP - a compound found in animal models of Parkinson’s disease. • Rotenone - a pesticide used in making animal models of Parkinson’s disease. •... Read more

How do dopaminergic neurons of the basal ganglia degenerate?

December 8, 2015 | Tags: > > Categories for this post are: Theories

Although, the exact mechanism for this phenomenon is not clear, there have been some theories. One such theory is that a normal mechanism of cell death called apoptosis may be accelerated. Apoptosis is a natural part of all systems; whereby a cell, which has grown old or begins to malfunction, undergoes a cascade of events that dismantle it before replacing it with a new cell. An example of... Read more